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9.843 0 0 9.843 165.8267 183.1747 Tm
[(I-ITFSI\))-395.4(was)-391(tested)-389.1(by)-388.1(thin-layer)]TJ
-10.546 -1.1116 TD
[(radiochromatography)-349.5(\(TLRC\).)-342.7(After)-341.7(30)-336.3(minutes)-344.2(of)-342(incuba-)]TJ
0 -1.1174 TD
(tion,)Tj
7.3823 0 0 6.5614 82.4315 165.6567 Tm
(131)Tj
9.843 0 0 9.843 93.5433 161.2346 Tm
[(I-labeled)-267(compound)-258.9(was)-264.3(spotted)-262.4(on)-261.4(cellulose-c)-11.2(oated)]TJ
-3.2024 -1.1116 TD
[(plastic)-401.9(\(ITLC-cellulose\))-410.5(sheets)-400.3(\(1)]TJ
/F6 1 Tf
14.071 0 TD
()Tj
/F4 1 Tf
.72 0 TD
[(10)-169.2(cm;)-397.5(Merck\))-401.4(and)-401.9(the)]TJ
-14.7909 -1.1116 TD
[(sheets)-348.5(were)-347.4(developed)-347.6(in)-347.9(two)-344.1(different)-346.5(mobile)-349.1(phases.)-346(The)]TJ
0 -1.1174 TD
[(dev)12.8(elo)12.7(ped)-257.9(ITL)17.4(C-c)11.8(ell)12.6(ulo)13.8(se)-262.4(she)13(ets)-257.8(wer)12(e)-267.2(rem)17.4(ove)12.8(d)-266(fro)14(m)-267.3(mob)12.7(ile)]TJ
0 -1.1116 TD
[(pha)12.8(ses)-257.5(and)-257.9(all)12.6(ow)14.2(ed)-262.5(to)-261.5(dry)14(.)-268.4(T)0(h)13.9(en,)-260.2(the)-258(she)13(et)13.8(s)-265.8(wer)12(e)-267.2(sca)11.8(nne)12.8(d)-266(o)0(n)]TJ
T*
[(a)-330.6(TLC)-317.7(sca)11.8(nne)12.8(r)-329.4(\(Bi)12.8(oSc)13(an)-320.1(AR-)12.1(200)14(0\).)]TJ
/F10 1 Tf
8.9663 0 0 8.9663 62.022 84.0189 Tm
(Lipophilicity)Tj
/F4 1 Tf
9.843 0 0 9.843 72 67.5779 Tm
[(Ana)11.9(lys)14(is)-238.3(of)-238.3(th)15(e)-244.2(lip)13.7(oph)14(ili)13.6(cit)12.6(y)-243(o)0(f)]TJ
7.3823 0 0 6.5614 194.1732 71.9433 Tm
[(13)17(1)]TJ
9.843 0 0 9.843 205.1149 67.5779 Tm
[(I-l)13.9(abe)11.7(led)-229.2(com)11.6(pou)14(nd)-238.3(was)]TJ
-14.5375 -1.1174 TD
[(car)11.7(rie)12.7(d)-179.6(out)-170.5(by)-175(mi)13.7(xin)13.8(g)-179.6(5)0(0)]TJ
/F8 1 Tf
9.7224 0 TD
(l)Tj
/F4 1 Tf
.5472 0 TD
.1808 Tc
[(Lo)180.8(f)]TJ
7.3823 0 0 6.5614 180.8503 60.9449 Tm
0 Tc
(131)Tj
9.843 0 0 9.843 191.7921 56.5795 Tm
[(I-l)13.9(abe)11.7(led)-171.6(im)13.7(ida)12.7(zol)12.7(ium)12.6(-TF)13(SI)]TJ
12.32 67.9242 TD
[(in)-353.7(3)-156.6(m)0(L)-350.2(o)0(f)-347.7(n-o)14(cta)11.5(nol)-343.3(and)-344.3(wat)11.8(er.)-346.6(Th)13.9(e)-359.4(m)0(i)13.7(xtu)13.9(re)-348.9(was)-345(mix)12.6(ed)-348.9(in)]TJ
0 -1.1174 TD
[(mag)11.6(net)12.7(ic)-297.2(mi)13.7(xer)-292.4(for)-285.5(1)-300.6(hou)14(r.)-292.5(For)-291.1(sep)13(ara)11.7(tio)19.5(n)-300.6(o)0(f)-295.9(the)-286.8(pha)12.8(ses)13.2(,)-297.2(the)]TJ
0 -1.1116 TD
[(mix)12.6(tur)13.9(e)-215.4(w)0(a)13(s)-214(cen)11.7(tri)13.7(fug)14(ed)-204.9(\(25)14(00)-157.7(rpm)12.8(,)-210.8(5)-208.4(min)12.6(ute)12.7(s\).)-201.2(The)17.4(n,)-206.1(500)]TJ
/F8 1 Tf
23.131 0 TD
(l)Tj
/F4 1 Tf
.5472 0 TD
(L)Tj
-23.6781 -1.1116 TD
[(of)-198(bot)13.8(h)-196.9(org)14(ani)12.7(c)-198.1(and)-194.5(wat)11.8(er)-193.4(pha)12.8(ses)-188.4(was)-195.2(tak)18.4(en)-199.2(and)-188.8(cou)12.8(nte)12.7(d)-196.9(usi)14(ng)]TJ
T*
[(a)-278.7(C)0(d)-268.2(\(Te)11.7(\))-277.5(RAD)-265.3(501)-268.2(sin)14(gle)12.7(-ch)12.9(an)13.9(nel)-269.5(ana)11.7(lyz)18.4(er.)]TJ
/F10 1 Tf
8.9663 0 0 8.9663 313.0582 657.9211 Tm
[(Human)-340.2(serum)-328.2(stability)-341(study)]TJ
/F4 1 Tf
9.843 0 0 9.843 323.0361 641.4802 Tm
[(The)-408.8(radiolabeled)-409.9(compound)-408.6(was)-408.3(added)-405.3(on)-405.4(fresh)-409.6(human)]TJ
-1.0137 -1.1174 TD
[(serum)-589.4(and)-592(incubated)-589.6(at)-585.2(37)]TJ
/F6 1 Tf
11.8823 0 TD
()Tj
/F4 1 Tf
.3974 0 TD
[(C.)-587.3(The)-587.4(quality)-591(control)-585.1(was)]TJ
-12.2797 -1.1116 TD
[(checked)-300.4(by)-295.9(taking)-296(samples)-293.2(at)-297.2(various)-296.8(times)-295.9(\(30)-291.3(minutes,)-295.8(1)]TJ
T*
[(3,)-338.6(and)-332.8(24)-330.5(hours\))-334.7(using)-333.7(the)-338.7(TLRC)-331.4(method.)]TJ
/F10 1 Tf
8.9663 0 0 8.9663 313.0582 585.6943 Tm
(Biodistribution)Tj
/F4 1 Tf
9.843 0 0 9.843 323.0361 569.2534 Tm
[(The)-564.4(animal)-563.4(experiment)-568.9(was)-563.8(approved)-564(by)-560.9(the)-563.3(Animal)]TJ
-1.0137 -1.1174 TD
[(Ethics)-314.3(Committee)-315.6(of)-307.4(Dokuz)-312.8(Eylu)]TJ
13.2012 .0115 TD
()Tj
.4147 -.0115 TD
[(l)-312.2(University.)]TJ
/F5 1 Tf
5.3796 0 TD
[(In)-313.2(vivo)]TJ
/F4 1 Tf
3.1333 0 TD
(study)Tj
-22.1288 -1.1116 TD
(of)Tj
7.3823 0 0 6.5614 324.6235 551.6786 Tm
(131)Tj
9.843 0 0 9.843 335.7353 547.3132 Tm
[(I-ITFSI)-342.5(was)-339.2(carried)-345.3(out)-337.5(using)-345.3(9)-335.2(female)-345.5(albino)-342.1(Wistar)]TJ
-2.3039 -1.1116 TD
[(rats.)-366(The)-368.5(imidazolium-TFSI)-363.6(salt)-368.5(\(500)]TJ
/F8 1 Tf
15.58 0 TD
(l)Tj
/F4 1 Tf
.5529 0 TD
[(g\))-365(was)-362.2(labeled)-368.6(with)]TJ
-16.1329 -1.1174 TD
(Na)Tj
7.3823 0 0 6.5614 324.5668 529.7951 Tm
(131)Tj
9.843 0 0 9.843 335.6786 525.3731 Tm
[(I)-715.3(through)-716.3(the)-718.8(iodogen)-717.4(method.)-721(The)-714.1(radiolabeled)]TJ
-2.2981 -1.1116 TD
[(imidazoliu)-9.3(m-TFSI)-256.3(salt)-259.1(\(specic)-259.7(activity:)-260.6(268.12)-170.2(MBq/)]TJ
/F8 1 Tf
21.8466 0 TD
(l)Tj
/F4 1 Tf
.5529 0 TD
(mol\))Tj
-22.3995 -1.1116 TD
(\(300)Tj
/F8 1 Tf
2.0044 0 TD
(l)Tj
/F4 1 Tf
.5529 0 TD
[(L\))-458.4(was)-465.9(intravenously)-466.1(injected)-461.9(through)-462.8(the)-459.6(tail)-466.7(vein)]TJ
-2.5573 -1.1174 TD
[(after)-480.2(weighing)-477.6(the)-476.9(rats.)-475.4(Three)-481.3(animals)-477.9(were)-474.1(sacriced)-480.9(at)]TJ
0 -1.1116 TD
[(each)-520.5(time)-513.9(point)-518.4(\(30,)-513.6(60,)-512.5(and)-517.1(120)-510.2(minutes)-517(postinjection\))]TJ
T*
[(under)-594.1(anesthesia)-597.3(following)-592.9(injection.)-592.2(Organs)-590.1(of)-589.7(interest)]TJ
T*
[(were)-370.4(excised,)-365.9(weighed,)-371.6(and)-361.6(counted)-367.3(by)-365.1(the)-367.5(Cd)-366.1(\(Te\)-RAD-)]TJ
0 -1.1174 TD
[(501)-337.4(single-channel)-337(analyzer.)]TJ
/F10 1 Tf
8.9663 0 0 8.9663 313.0582 425.7637 Tm
[(Cell)-336.3(culture)]TJ
/F4 1 Tf
9.843 0 0 9.843 323.0361 409.3228 Tm
[(Cell)-438.8(culture)-442.2(studies)-440.7(were)-439.5(carried)-437.5(out)-441.2(using)-437.4(the)-436.6(CaCo-2)]TJ
-1.0137 -1.1116 TD
[(cell)-433.2(line)-432([ATCC)-430.1(HTB-37,)-427.8(tissue:)-435.1(human)-428.4(colon,)-430.7(colorectal)]TJ
0 -1.1174 TD
[(adeno)-7.8(carcinoma])-270.4(and)-275.2(HEK-293)-269.8(cell)-277.7(line)-270.8([ATCC)-274.6(HEK293T/)]TJ
0 -1.1116 TD
[(17)-405.4(human)-411.1(epithelial)-406.8(kidney].)-404.1(These)-412(cells)-405.3(were)-405(cultured)-408.8(in)]TJ
T*
[(MEM)-357.7(nonessential)-350.8(amino)-353.6(acid)-352.4(solution)-354.6(containing)-353.6(100)-348.9(IU/)]TJ
T*
[(mL)-390.5(penicillin)-394.1(G,)-385.5(100)-170.3(mg/mL)-389.4(streptomycin,)-389(and)-390.4(10%)-390.3(heat-)]TJ
0 -1.1174 TD
[(inactivated)-552.9(fetal)-549.5(bovine)-549.3(serum)-543.3(\(FBS\))-547.6(and)-551.6(maintained)-546(at)]TJ
0 -1.1116 TD
(37)Tj
/F6 1 Tf
1.0022 0 TD
()Tj
/F4 1 Tf
.3974 0 TD
[(C)-330.4(i)0(n)-336.4(a)0(n)-331.7(incubator)-340.8(containing)-336.3(5%)-331.6(CO)]TJ
7.3823 0 0 6.5614 475.9369 330.9731 Tm
(2)Tj
9.843 0 0 9.843 479.6219 332.6172 Tm
(.)Tj
/F10 1 Tf
8.9663 0 0 8.9663 313.0582 309.7133 Tm
[(Cytotoxicity)-336.7(assay)-336.2(of)-330.4(imidazolium-TFSI)-339.4(salt)]TJ
/F4 1 Tf
9.843 0 0 9.843 323.0361 293.2723 Tm
.0186 Tc
[(XT)-6.7(T)-1101.1(\().3(2,3-)-5.5(bis)-5.3(-\(2)-5.5(-met)-5.7(hox)-5.5(y-4)-5.5(-).3(ni)-5.7(tro-)-5.5(5-s)-5.3(u).2(lf)-5.5(oph)-5.5(eny)-5.5(l).1(\)-)-5.5(2H-)]TJ
-1.0137 -1.1116 TD
.0198 Tc
[(tetrazolium)-5.6(-5-carboxa)-5.5(nili)]TJ
10.7764 0 TD
.0208 Tc
[(d)2.4(e)-459.5(sal)2.3(t)-3.5(\))-458.3(a)1.3(ss)2.6(ay)-464.1(was)-463.9(u)2.4(s)2.6(e)-4.5(d)-458.4(t)2.3(o)-464.1(d)2.4(e-)]TJ
-10.7764 -1.1174 TD
.0184 Tc
[(t)-5.9(e)-1.1(rm)-7(ine)-254.6(t)-5.9(he)-254.6(IC)]TJ
7.3823 0 0 6.5614 372.6424 269.6881 Tm
.0222 Tc
(50)Tj
9.843 0 0 9.843 382.9038 271.3322 Tm
.0188 Tc
[(va)-6.5(lue)-254.2(o)-5.3(f)-253(i).3(mi)-5.5(daz)-6.5(o).4(liu)-5.3(m-TF)-5.2(SI)-253(s)-5.1(a)-.7(lt)-258.9(in)-253(Ca)-6.5(Co-)]TJ
-7.096 -1.1116 TD
0 Tc
[(2)-438.8(a)15(nd)-388.1(HE)24.5(K)15.3(-)16.2(2)16.2(9)0(3)-388.1(c)0(e)24.3(l)16.1(l)-404.4(l)16(i)16.1(n)0(e)25.4(s)16.4(.)-400.8(T)15(he)-389.3(nu)26.6(m)15(b)16.2(e)15(r)-404.2(o)16.2(f)-404.2(v)16.2(i)0(a)25.3(b)16.2(l)16.1(e)-405.4(c)15(e)15(l)0(l)26.3(s)-404.1(w)15.3(a)15(s)]TJ
T*
-.0155 Tc
[(d)-15.5(e)9.9(ter)-15.5(m)9.9(ined)-344.9(by)-339.1(me)-15.5(a)8.8(n).7(s)-344.7(o).7(f)-339.1(t)-15.5(h)11(e)-340.3(Cel)-15.5(l)-329(Pr)-15.5(o)11.1(l).6(if)-15.5(e)10(r).7(at)-15.5(i)10.8(o).7(n)-339.1(K)-15.5(i)10.1(t)-339.3(X)-15.5(T)9(T.)-341.5(The)]TJ
0 -1.1174 TD
0 Tc
[(st)26.7(u)16.2(d)16.2(y)-433.1(w)15.3(a)15(s)-427.1(p)0(e)25.4(r)16.2(f)16.2(o)0(r)26.6(m)15(e)15(d)-427.3(in)-417(a)-428.5(9)16.2(6-)26.6(w)15.3(e)15(l)16.1(l)-433.2(c)15(u)16.2(l)16.1(t)0(u)26.5(r)16.2(e)-428.5(p)16.2(la)25.3(t)16.1(e)-428.5(by)-416.9(s)16.4(e)15(e)15(d)0(i)26.5(n)16.2(g)]TJ
0 -1.1116 TD
[(ea)24.3(c)15(h)-323.6(w)15.3(e)15(ll)-307.7(wi)25.6(t)16(h)-323.6(1)]TJ
/F6 1 Tf
6.8425 0 TD
()Tj
/F4 1 Tf
.7027 0 TD
(10)Tj
7.3823 0 0 6.5614 396.907 231.8739 Tm
(5)Tj
9.843 0 0 9.843 403.7668 227.5086 Tm
-.016 Tc
[(ce)-16(l)9.3(l)0(s.)-342(Fol)-16(l)10.3(owin)-16(g)-329.2(2)-339.6(days)-339.5(of)-339.6(i)-16(n)10.5(cuba)-16(t)9.3(i)0(on)-16(,)]TJ
-9.2155 -1.1116 TD
-.0162 Tc
[(5)-16.2(0)10.4(30)-16.2(0)]TJ
/F8 1 Tf
3.0814 0 TD
0 Tc
(l)Tj
/F4 1 Tf
.5357 0 TD
-.0159 Tc
[(M)-248.3(c)-.9(ompo)-15.9(u)10.7(nds)-247.2(pr)-15.9(e)9.6(p).3(ar)-15.9(e)9.6(d)-247.4(with)-247.4(MEM)-248.3(s).5(o)-15.9(l)10.6(uti)-15.9(o)10.6(n)-247.4(\().3(wit)-15.9(h)10.6(out)]TJ
-3.6171 -1.1174 TD
-.0157 Tc
[(F)-15.7(B)10(S\))-345.1(were)-340.5(a)-15.7(d)9.7(ded)-345.1(t).4(o)-339.3(eac)-15.7(h)-330.1(w)-.4(ell)-345.2(o).5(f)-339.3(t)-15.7(h)10.8(e)-340.5(96)-15.7(-)10.9(w)-.4(ell)-345.2(p).5(lat)-15.7(e)9.6(.)-341.7(A)-.4(fte)-15.7(r)-330.1(24)]TJ
0 -1.1116 TD
[(h)-15.8(o)10.8(urs)-15.8(,)-371.5(t)-15.8(h)10.7(e)-386.7(sol)-15.8(v)10.7(ent)-385.7(med)-15.8(i)10.7(a)-386.7(on)-385.5(th)-15.8(e)-376.3(cells)-385.3(w)-15.8(e)8.8(re)-386.7(re)-15.8(m)8.4(oved)-385.5(a)-.8(n)-15.8(d)-375.1(re-)]TJ
T*
[(p)-15.8(l)10.7(aced)-385.5(with)-379.8(M)-15.8(E)8.7(M)-380.7(s).6(olu)-15.8(t)10.7(ion)-379.8(c)-15.8(o)9.6(n).4(ta)-15.8(i)9.5(n).4(ing)-385.5(F).5(BS.)-382.1(A)-.5(ft)-15.8(e)9.5(r)-379.7(1)-379.8(h).4(o)-15.8(u)10.8(r)-379.7(o).4(f)]TJ
0 -1.1174 TD
0 Tc
[(in)26.5(c)15(u)16.2(ba)25.4(t)16.1(i)16(o)16.2(n)0(,)-361.6(5)16.2(0)]TJ
/F8 1 Tf
5.8519 0 TD
(l)Tj
/F4 1 Tf
.5414 0 TD
.3732 Tc
[(Ls)373.2(o)400(l)389.3(u)389.4(t)373.2(i)399.5(o)389.4(nf)389.4(r)373.2(o)399.8(mt)373.2(h)399.7(e)-3.4(X)388.5(T)388.2(T)-3.5(k)389.4(i)389.3(t)-2.4(w)388.5(a)388.2(sp)373.2(u)399.8(t)-2.4(i)389.3(n)-2.3(t)389.2(h)389.4(e)]TJ
-6.3933 -1.1116 TD
0 Tc
[(we)24.6(l)16.1(l)16.1(s)0(.)-344.2(T)0(h)25.4(r)16.2(e)15(e)-359.4(ho)26.6(u)16.2(r)16.2(s)-363.8(l)16(a)15(t)16.1(e)0(r)25.5(,)-360.5(a)15(b)16.2(s)16.4(o)0(r)26.6(b)16.2(a)15(n)0(c)25.4(e)-359.4(o)16.2(f)-358.2(th)26.5(e)-359.4(s)16.4(am)24.2(p)16.2(l)16.1(e)15(s)-363.8(i)16.1(n)-358.2(w)15.3(e)0(l)25.3(l)16.1(s)]TJ
T*
-.0158 Tc
[(w)-15.8(a)8.8(s)-368(m)-.8(e)-15.8(a)8.5(sur)-15.8(e)9.7(d)-368.2(i).3(n)-374(a)-369.4(micr)-15.8(o)10.8(p).4(la)-15.8(t)9.5(e)-369.4(re)-15.8(a)8.5(d).4(er)-374(\(Var)-15.8(i)10.7(o).4(sk)-15.8(a)9.6(n)-368.2(Fl)-15.8(a)9.5(s).6(h)-368.2(M)-15.8(u)9.9(l).2(-)]TJ
T*
-.0156 Tc
[(t)-15.6(i)10.7(mode)-328.9(Reade)-15.6(r)9.9(-Th)-15.6(e)9.8(rmo\))-327.7(at)-322.1(45)-15.6(0)11(/).4(63)-15.6(0)-156(n).6(m.)-324.3(Then)-15.6(,)-313.9(t).4(he)-323.1(p)-15.6(e)9.8(rcen)-15.6(t)10.9(a)-.6(ge)]TJ
0 -1.1174 TD
0 Tc
[(of)-307.4(c)15(y)16.2(t)16.1(o)0(t)26.5(o)16.2(x)16.2(i)0(c)25.3(i)16.1(t)16(y)-317.9(wa)24.6(s)-317.7(c)15(a)15(l)16.1(cu)25.4(l)16.1(a)15(t)16.1(e)0(d)25.4(.)]TJ
/F10 1 Tf
8.9663 0 0 8.9663 313.0582 105.959 Tm
[(Intracellular)-340(uptakes)-330.1(of)]TJ
6.7246 0 0 5.9768 406.9416 109.9275 Tm
(131)Tj
8.9663 0 0 8.9663 418.1101 105.959 Tm
[(I-imidazolium-TFSI)-338.7(salt)]TJ
/F4 1 Tf
9.843 0 0 9.843 323.0361 89.5181 Tm
(The)Tj
/F5 1 Tf
1.9065 0 TD
[(in)-342.1(vitro)]TJ
/F4 1 Tf
3.3579 0 TD
[(cellular)-346.7(uptake)-343.1(of)]TJ
7.3823 0 0 6.5614 449.2345 93.8834 Tm
(131)Tj
9.843 0 0 9.843 460.3463 89.5181 Tm
[(I-labeled)-341.9(imidazolium-)]TJ
-14.9637 -1.1116 TD
[(TFSI)-471.8(salt)-466.4(was)-465.9(performed)-468.4(using)-466.2(the)-465.4(CaCo-2)-470.6(cell)-467.8(line)-466.6(and)]TJ
0 -1.1174 TD
[(HEK-2)-8.4(93)-238.3(cell)-243.1(line)-242(as)-245.1(control)-245.3(group.)-239.3(The)-241.8(cells)-244(were)-249.5(placed)-240.6(in)]TJ
0 -1.1116 TD
[(24-well)-292.2(culture)-292.5(plates)-297(\(1)]TJ
/F6 1 Tf
10.068 0 TD
()Tj
/F4 1 Tf
.72 0 TD
(10)Tj
7.3823 0 0 6.5614 429.1086 61.0016 Tm
(5)Tj
9.843 0 0 9.843 435.6282 56.6362 Tm
[(cells)-295.9(in)-284.5(each)-295.9(well\))-290(at)-291.5(37)]TJ
/F6 1 Tf
9.7109 0 TD
()Tj
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