Protection by selective mTORC2 inhibition of Zymosan-induced hypotension and systemic inflammation mediated via IKKα/IκB-α/ NF-κB activation
PROSTAGLANDINS & OTHER LIPID MEDIATORS, vol. 175, no. , pp. 106918–
Zainab Sabrie, Zaınab Sabrıe, Meryem Temiz Reşitoğlu, Taşkın Kalkan, Banu Kılıç, Bahar Tunçtan, Kafa...
mTORC2 inhibition by JR-AB2-011 improves IL-1β-induced inflammation, catabolic response, and apoptosis in human chondrocytes through IκB-α/NF-κB p65
Cellular and Molecular Biology, vol. 70, no. 9, pp. 37–43
Meryem Temiz Reşitoğlu, Zainab Sabrie, Rukiye Nalan Tiftik, Zaınab Sabrıe, Ayça Aktaş Şüküroğlu, Sey...
mTOR inhibition modulates apoptosis and oxidative stress in hindlimb ischemia/reperfusion injury
CUKUROVA MEDICAL JOURNAL, vol. 48, no. 4, pp. 1322–1332
Zarife Pire, Demet Sinem Güden, Meryem Temiz Reşitoğlu, Şefika Pınar Şenol, Özden Vezir, Nehir Sucu,...
NLRX1 ligand, docosahexaenoic acid, ameliorates LPS-induced inflammatory hyperalgesia by decreasing TRAF6/IKK/IkB-a/NF-kB signaling pathway activity
Cellular and Molecular Biology, vol. 69, no. 9, pp. 15–23
Dilşah Ezgi Yılmaz, Şefika Pınar Şenol, Meryem Temiz Reşitoğlu, Seyhan Şahan Fırat, Bahar Tunçtan
Pro-inflammatory GPR75 and anti-apoptotic phospholipase signaling pathways contribute to the ameliorating effect of soluble epoxide hydrolase inhibition on chronic experimental autoimmune encephalomyelitis in mice
CELLULAR AND MOLECULAR BIOLOGY, vol. 69, no. 10, pp. 9–16
Mehmet Furkan Horat, Şefika Pınar Şenol, Ömer Bahçeli, Meryem Temiz Reşitoğlu, Seyhan Şahan Fırat, M...
NLRX1 ligand, docosahexaenoic acid, ameliorates LPS-induced inflammatory hyperalgesia by decreasing TRAF6/IKK/IκB-α/NF-κB signaling pathway activity
CELLULAR AND MOLECULAR BIOLOGY, vol. 69, no. 9, pp. 15–23
Dilşah Ezgi Yılmaz, Şefika Pınar Şenol, Meryem Temiz Reşitoğlu, Seyhan Şahan Fırat, Bahar Tunçtan
Pyroptosis and necroptosis inhibitor necrosulfonamide ameliorates lipopolysaccharide-induced inflammatory hyperalgesia in mice
Pharmacia, vol. 70, no. 4, pp. 1345–1354
Beyza Özgen, Şefika Pınar Şenol, Dilşah Ezgi Yılmaz, Dilşah Ezgi Küçük, Meryem Temiz Reşitoğlu, Ömer...
Bexarotene Ameliorates LPS-Induced Hyperalgesia: Contribution of TLR4/MyD88-Dependent Pro-Inflammatory, Anti-Apoptotic and Anti-Inflammatory Signaling Pathways
INTERNATIONAL JOURNAL OF PHARMACOLOGY, vol. 18, no. 6, pp. 1171–1188
Ömer Bahçeli, Şefika Pınar Şenol, Meryem Temiz Reşitoğlu, Furkan Horat, Mehmet Furkan Horat, Seyhan ...
Activation of GPR75 Signaling Pathway Contributes to the Effect of a 20-HETE Mimetic, 5,14-HEDGE, to Prevent Hypotensive and Tachycardic Responses to Lipopolysaccharide in a Rat Model of Septic Shock
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, vol. 80, no. 2, pp. 276–293
Bahar Tunçtan, Şefika Pınar Şenol, Meryem Temiz Reşitoğlu, Dilsah Ezgi Yılmaz, Dilşah Ezgi Yılmaz, D...
Pharmacological Inhibition of Mammalian Target of Rapamycin Attenuates Deoxycorticosterone Acetate Salt-Induced Hypertension and Related Pathophysiology: Regulation of Oxidative Stress, Inflammation, and Cardiovascular Hypertrophy in Male Rats
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, vol. 79, no. 3, pp. 355–367
Meryem Temiz Reşitoğlu, Şakir Necat Yılmaz, Demet Sinem Güden, Şefika Pınar Şenol, Özden Vezir, Nehi...
Soluble epoxide hydrolase inhibitor trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)urea prevents hyperalgesia through regulating NLRC4 inflammasome-related pro-inflammatory and anti-inflammatory signaling pathways in the lipopolysaccharide-induced pain mouse model
DRUG DEVELOPMENT RESEARCH, vol. 82, no. 6, pp. 815–825
Ali Cağli, Ali Cagli, Ali Caglı, Şefika Pınar Şenol, Meryem Temiz Reşitoğlu, Demet Sinem Güden, Ayşe...
Suppression of TLR4/MyD88/TAK1/NF-κB/COX-2 Signaling Pathway in the Central Nervous System by Bexarotene, a Selective RXR Agonist, Prevents Hyperalgesia in the Lipopolysaccharide-Induced Pain Mouse Model
NEUROCHEMICAL RESEARCH, vol. 46, no. 3, pp. 624–637
Şefika Pınar Şenol, Meryem Temiz Reşitoğlu, Demet Sinem Güden Yıldırım, Demet Sinem Güden, Ayşe Niha...
Involvement of Rho-kinase/IκB-α/INF-κB activation in IL-1β-induced inflammatory response and oxidative stress in human chondrocytes
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, vol. 99, no. 4, pp. 418–426
Rukiye Nalan Tiftik, Meryem Temiz Reşitoğlu, Demet Sinem Güden, Gülsen Bayrak, G Bayrak, İsmail Ün, ...
PPARA/β/G and c-Jun contribute to preventive effect of bexarotene, a RXR agonist, against LPS-induced inflammatory hyperalgesia
, vol. 178, no. 24, pp. 4923–5006
Ömer Bahçeli, Bahar Tunçtan, Mehmet Furkan Horat, Şefika Pınar Şenol, Meryem Temiz Reşitoğlu, Demet ...
mTOR inhibition as a possible pharmacological target in the management of systemic inflammatory response and associated neuroinflammation by lipopolysaccharide challenge in rats
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, vol. 99, no. 9, pp. 921–934
Demet Sinem Güden, Meryem Temiz Reşitoğlu, Şefika Pınar Şenol, Deniz Kibar, Şakir Necat Yılmaz, Baha...
Pharmacological inhibition of soluble epoxide hydrolase attenuates chronic experimental autoimmune encephalomyelitis by modulating inflammatory and anti-inflammatory pathways in an inflammasome-dependent and -independent manner
INFLAMMOPHARMACOLOGY, vol. 28, no. 6, pp. 1509–1524
Merve Biliktu, Şefika Pınar Şenol, Meryem Temiz Reşitoğlu, Demet Sinem Güden, Furkan Horat, Mehmet F...
Targeting mTOR: up-to-date mTOR inhibitors.
Bioorganic Medicinal Chemistry Reports, vol. , no. , pp. 1–14
Banu Kılıç, Meryem Temiz Reşitoğlu, Seyhan Şahan Fırat
Modulation of oxidative/nitrosative stress and inflammatory response by rapamycin in target and distant organs in rats exposed to hindlimb ischemia/reperfusion: The role of mTOR.
Canadian Journal of Physiology and Pharmacology, vol. , no. , pp. –
Zumrut Kocak, Meryem Temiz Reşitoğlu, Demet Sinem Güden, Özden Vezir, Nehir Sucu, Senay Balcı, Lülüf...
NF-κB activation mediates LPS- or zymosan-induced hypotension and inflammation reversed by BAY61-3606, a selective Syk inhibitor, in rat models of septic and non-septic shock
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol. 46, no. 2, pp. 173–182
Seyhan Şahan Fırat, Meryem Temiz Reşitoğlu, Demet Sinem Güden, Şefika Pınar Şenol, Ayşe Nihal Sarı, ...
Modulation of oxidative–nitrosative stress and inflammatory response by rapamycin in target and distant organs in rats exposed to hindlimb ischemia–reperfusion: the role of mammalian target of rapamycin
Canadian Journal of Physiology and Pharmacology, vol. 97, no. 12, pp. 1193–1203
Zümrüt Koçak, Zumrut Kocak, Meryem Temiz Reşitoğlu, Meryem Temiz-Resitoglu, Demet Sinem Güden, Demet...
Eicosanoids derived from cytochrome P450 pathway of arachidonic acid and inflammatory shock
PROSTAGLANDINS OTHER LIPID MEDIATORS, vol. 145, no. , pp. 106377–
Bahar Tunçtan, Şefika Pınar Şenol, Meryem Temiz Reşitoğlu, Demet Sinem Güden, Seyhan Şahan Fırat, Jo...
mTOR contributes to LPS-triggered neuroinflammation: Modulation of I kappa B-alpha/NF-kappa B/HIF-1 alpha signaling pathway
, vol. 392, no. S1, pp. 1–88
Demet Sinem Güden, Meryem Temiz Reşitoğlu, Şefika Pınar Şenol, Deniz Kibar, Şakir Necat Yılmaz, Baha...
Activation of mTOR/IκB-α/NF-κB pathway contributes to LPS-induced hypotension and inflammation in rats
European Journal of Pharmacology, vol. 802, no. , pp. 7–19
Meryem Temiz Reşitoğlu, Şefika Pınar Küçükkavruk, Şefika Pınar Şenol, Demet Sinem Güden, Pelin Cecen...
The role of Syk/IĸB-α/NF-ĸB pathway activation in the reversal effect of BAY 61-3606, a selective Syk inhibitor, on hypotension and inflammation in a rat model of zymosan-induced non-septic shock
Clinical and Experimental Pharmacology and Physiology, vol. 45, no. 2, pp. 155–165
Demet Unsal, Demet Ünsal, Meltem Kaçan, Meryem Temiz Reşitoğlu, Demet S Guden, Demet Sinem Güden, Be...
Bexarotene, a selective RXRα agonist, reverses hypotension associated with inflammation and tissue injury in a rat model of septic shock
Inflammation, vol. 41, no. 1, pp. 337–355
Bahar Tunçtan, Şefika Pınar Küçükkavruk, Meryem Temiz Reşitoğlu, Demet Sinem Güden, Ayşe Nihal Sarı,...
Protection by mTOR inhibition on zymosan-induced systemic inflammatory response and oxidative/nitrossative stress: contribution of mTOR/MEK1/ERK1/2/IKKβ/IκB-α/NF-κB signalling pathway.
Inflammation, vol. 41, no. 1, pp. 276–298
Seyhan Şahan Fırat, Meryem Temiz Reşitoğlu, Demet Sinem Güden, Şefika Pınar Küçükkavruk, Bahar Tunçt...
Inhibition of NLRP3 Inflammasome Contributes to Protective Effect of 5,14-HEDGE Against Lipopolysaccharide-induced Septic Shock
International Journal of Pharmacology, vol. 13, no. 6, pp. 654–666
Bahar Tunçtan, Şefika Pınar Küçükkavruk, Meryem Temiz Reşitoğlu, Demet Sinem Güden, Ayşe Nihal Sarı,...
Inhibition of NLRP3 Inflammasome Prevents LPS-Induced Inflammatory Hyperalgesia in Mice: Contribution of NF-κB, Caspase-1/11, ASC, NOX, and NOS Isoforms
Inflammation, vol. 40, no. 2, pp. 366–386
Abdurrahman Dolunay, Şefika Pınar Küçükkavruk, Şefika Pınar Şenol, Meryem Temiz Reşitoğlu, Demet Sin...
Contribution of PPAR AP 1 importin 3 and RXR to the protective effect of 5 14 HEDGE a 20 HETE mimetic against hypotension tachycardia and inflammation in a rat model of septic shock
Inflammation Research, vol. 65, no. 5, pp. 367–387
Şefika Pınar Şenol, Meryem Temiz Reşitoğlu, Demet Sinem Güden, Pelin Çeçen, Pelin Cecen, Ayşe Nihal ...
Inhibition of mTOR protects against skeletal muscle and kidney injury following hindlimb ischemia-reperfusion in rats by regulating MEK1/ERK1/2 activity
CUKUROVA MEDICAL JOURNAL, vol. 47, no. 1, pp. 219–232
Çağla Akıncı Uysal, Meryem Temiz Reşitoğlu, Demet Sinem Güden, Şefika Pınar Şenol, Özden Vezir, Nehi...
Yaşa bağlı gelişen bozukluklarda polifenoller ve hedefleri mTOR sinyal ileti yolu.
Mersin Üniversitesi Sağlık Bilimleri Dergisi, vol. 12, no. 3, pp. 542–552
Meryem Temiz Reşitoğlu, Seyhan Şahan Fırat
Hipertansiyon araştırmalarında kullanılan deneysel modeller
Marmara Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, vol. 6, no. , pp. 35–43
Meryem Temiz Reşitoğlu, Demet Sinem Güden, Seyhan Şahan Fırat
Sepsis ve septik şok patojenezinde endotelin 1 in rolü ve tedavide yeni yaklaşımlar
Marmara Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, vol. 5, no. 3, pp. 178–190
Demet Sinem Güden, Meryem Temiz Reşitoğlu, Meryem Temiz, Bahar Tunçtan, Seyhan Şahan Fırat
Sepsis ve septik şok patojenezinde endotelin 1 in rolü ve tedavide yeni yaklaşımlar
Marmara Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, vol. 5, no. 3, pp. 178–190
Demet Sinem Güden, Meryem Temiz Reşitoğlu, Meryem Temiz, Bahar Tunçtan, Seyhan Şahan Fırat
Zimosan Sinyal İletisi ve Dalak Tirozin Kinazı
Marmara Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, vol. 4, no. 3, pp. 148–157
Demet Ünsal, Meryem Temiz, Meryem Temiz Reşitoğlu, Bahar Tunçtan, Seyhan Şahan Fırat
Zimosan Sinyal İletisi ve Dalak Tirozin Kinazı
Marmara Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, vol. 4, no. 3, pp. 148–157
Demet Ünsal, Meryem Temiz, Meryem Temiz Reşitoğlu, Bahar Tunçtan, Seyhan Şahan Fırat